Difference between DNA Replication in E.coli and Mammalian cells

DNA replication in E.coli
DNA Replication in E.coli

1. DNA polymerase III is involved in leading strand synthesis.
2. Lagging strand synthesis is initiated by primase.
3. Extension of RNA primer into Okazaki fragments is carried out by DNA polymerase III.
4. Primer removal and filling of gaps between Okazaki fragments is carried out by DNA polymerase I.



DNA replication in Mammalian cells

DNA replication in Mammalian cells
1. DNA polymerase delta is involved in leading strand synthesis.
2. Lagging strand synthesis is initiated by complex of primase and DNA polymerase alpha.
3. Extension of RNA primer into Okazaki fragments is carried out by DNA polymerase delta.
4. Primer removal and filling of gaps between Okazaki fragments is carried out by DNA polymerase delta.
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