Difference between Type I and type II Nuclear receptors

Type I vs type II Nuclear receptors

Nuclear receptors are a family of ligand activated transcription factors that are activated by steroid hormones, such as estrogen and various other lipid-soluble signals such as retinoic acid.

Type I Nuclear receptors	Type II Nuclear receptors
Intracellular cytoplasmic receptor	Intracellular nuclear receptor
Ligand (signaling molecule) binds to the intracellular cytoplasmic receptor and then translocate to the nucleus	The receptor is in the nucleus even before ligand binding. Ligand bind to the receptor inside the nucleus
The receptor is bound to HSP (Heat Shock Protein) in its inactive state in the cytoplasm	The receptor located in the nucleus is bound to corepressor in its inactive state
The receptor is not bound to specific DNA sequence or HREs (Hormone response elements) before ligand binding.	The receptor-corepressor complex is bound to specific DNA sequence or HREs (Hormone response elements) even before ligand binding
Ligand binding to the receptor detaches HSP, dimerizes and ligand-receptor complex translocate to the nucleus and binds to HRE	Ligand binding to the receptor detaches corepressor, and coactivator proteins are recruited
Nuclear receptor dimer binds to HRE and causes transcription and translation of associated genes leading to cellular response	Nuclear receptor dimer with coactivators causes transcription and translation of associated genes leading to cellular response
Type I nuclear receptor example: Estrogen receptor, Progesterone receptor Learn More: Type I and type II Nuclear receptor Pathway steps	Type II nuclear receptor example: Retinoic acid receptor, Thyroid receptor Watch Our Video on Intracellular Receptor Signaling || Type I and Type II Nuclear Receptor Signaling and Structure