Difference between Turner Syndrome and Klinefelter Syndrome

 Turner Syndrome vs Klinefelter Syndrome comparison

Both Turner Syndrome and Klinefelter Syndrome are chromosomal conditions caused by aneuploidy (an abnormal number of chromosomes) in the sex chromosomes (allosomes).

Watch our 2 minute video here: Turner Syndrome and Klinefelter Syndrome

Turner Syndrome	Klinefelter Syndrome
Affected Sex: Female	Male
Karyotype: 45, X (Monosomy)	47, XXY (Trisomy)
Primary Cause: Missing X chromosome	Extra X chromosome
Height: Typically, short	Typically, tall
Fertility: Generally infertile	Generally infertile
Treatment: Growth hormone (for height), estrogen/progesterone replacement (for puberty/menstruation).	Testosterone therapy (for puberty/male characteristics), fertility support.
Occurrence: It occurs in roughly 1 in 2,000 -2500 live-born female infants	Klinefelter syndrome occurs in roughly 1 in 500 to 1,000 male infants.
Reason: The most common cause is caused by the complete or partial absence of one X chromosome, often due to an error in the father's sperm or mother's egg through a random cell division error called nondisjunction.	The most common cause is non disjunction during meiosis (sperm or egg formation) where chromosomes fail to separate, resulting in a gamete with an extra X chromosome.