Difference between Citric acid cycle and Electron Transport Chain
Cellular Respiration is a catabolic process where respiratory
substrates like glucose is broken down or oxidised to form carbon dioxide and
water with release of energy as ATP. This energy is used to drive all cellular
activities.
Stages
of Cellular respiration
1. Glycolysis: glucose broken down to two pyruvate molecules
2. Link reaction: Pyruvate transported to mitochondria and
converted to Acetyl CoA with the release of CO2
3.Krebs cycle: Acetyl CoA enters krebs cycle by combining with
oxaloacetate to form citrate; the first compound formed in Krebs cycle (therefore
krebs cycle also called as citric acid cycle)
4. Electron transport chain and oxidative phosphorylation: NADH and
FADH2 produced in Krebs cycle enters electron transport chain, creating a
proton motive force and finally produces ATP with O2 as terminal electron
acceptor forming H2O.
Krebs Cycle vs Electron Transport Chain (ETC)
Krebs
Cycle
|
Electron Transport Chain (ETC)
|
Krebs cycle occurs in the mitochondrial
matrix
|
Electron transport chain occurs in the mitochondrial inner
membrane (cristae)
|
Net gain of ATP per
glucose molecule is 2
|
Net gain of ATP per
glucose molecule is 34 (1 NADH=3 ATP & 1 FADH2=2 ATP)
|
Reduced NAD and FAD are produced as NADH and FADH2
(6 NADH & 2FADH2 per glucose molecule)
|
NADH and FADH2 are reoxidised to NAD and
FAD
|
The phosphorylation
for ATP synthesis is substrate level phosphorylation
|
The phosphorylation
for ATP synthesis is oxidative phosphorylation
|
CO2 release or decarboxylation occurs at various
steps
|
No decarboxylation
|
Chemiosmosis; not involved in ATP production
|
Chemiosmosis (proton gradient formation and
associated ATP synthesis) involved in ATP production
|
Aerobic process, but oxygen not directly involved.
It needs byproducts from ETC like NAD and FAD
|
Aerobic process; oxygen directly involved as
terminal electron acceptor
|
Carbon dioxide is released as a waste product of
these reactions.
|
Water is released as a waste product of these
reactions.
|
Extremely helpful thank you !
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