|
Competitive
Inhibition |
Allosteric
Inhibition |
|
The inhibitor binds to the active site
of enzyme. |
The inhibitor attaches to an area
other than the active site. |
|
It does not change the conformation of
enzyme. |
The conformation of the enzyme is changed. |
|
The active site is swamped by inhibitor |
The conformation of active site is changed
so that substrate cannot combine with it |
|
The inhibitor resembles the substrate
in its broad structure. |
The inhibitor has no structural
similarity with the substrate. |
|
The inhibitor is not connected by
metabolic pathway catalyzed by the enzyme. |
Inhibitor is a product or intermediate
of the metabolic pathway connected with that enzyme. |
|
It does not have a regulatory function |
It has a regulatory function as it stops
the excess formation of a product. |
Competitive inhibition vs Allosteric inhibition